Sigma-Aldrich 440744 Polycaprolactone average Mn 80,000 500 gr
| Sigma-Aldrich 440744 Polycaprolactone average Mn 80,000 500 gr |
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Synonym(s): 6-Caprolactone polymer, 2-Oxepanone homopolymer
Linear Formula: (C6H10O2)n
NACRES: NA.23 |
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PROPERTIES
Quality Level 200
form pellets (~3 mm)
mol wt average Mn 80,000
impurities <0.5% water
mp 60 °C (lit.)
density 1.145 g/mL at 25 °C
Mw/Mn <2
DESCRIPTION
General description
Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
* It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
* Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.[1]
Application
* PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
* Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.[1]
* PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.[2]
* Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.
Packaging
5, 250, 500 g in poly bottle
Features and Benefits
Biodegradable polymer Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates. |
