Sigma Aldrich 57668 D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate 5 gr
Marka
Stok Kodu
LB.SA.57668-5G
Kısa Bilgi
Synonym(s): D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS CAS Number: 9002-96-4 MDL number: MFCD00146616 UNSPSC Code: 12352205 eCl@ss: 34058007 NACRES: NA.79
Bilgi
CAS Number: 9002-96-4
| Sigma Aldrich 57668 D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate 5 gr |
| Synonym(s): D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS CAS Number: 9002-96-4 MDL number: MFCD00146616 UNSPSC Code: 12352205 eCl@ss: 34058007 NACRES: NA.79 |
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PROPERTIES
biological source synthetic
Quality Level 200 product line BioXtra form powder, crystals or chunks composition α-tocopherol, ≥25% concentration ≥25% (ALPHA TOCOPHEROL) color white to light brown mp >36 °C solubility H2O: 1 g/10 mL, clear to faintly turbid, colorless to faintly yellow cation traces Al: ≤5 mg/kg Ba: ≤5 mg/kg Bi: ≤5 mg/kg Ca: ≤5 mg/kg Cd: ≤5 mg/kg Co: ≤5 mg/kg Cr: ≤5 mg/kg Cu: ≤5 mg/kg Fe: ≤5 mg/kg K: ≤50 mg/kg Li: ≤5 mg/kg Mg: ≤5 mg/kg Mn: ≤5 mg/kg Mo: ≤5 mg/kg Na: ≤50 mg/kg Ni: ≤5 mg/kg Pb: ≤5 mg/kg Sr: ≤5 mg/kg Zn: ≤5 mg/kg storage temp. 2-8°C SMILES string CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C InChI 1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 InChI key AOBORMOPSGHCAX-UHFFFAOYSA-N DESCRIPTION General description Tocofersolan, also known as Vitamin E-TPGS, is a nonionic surfactant and a synthetic polyethylene glycol derivative of α-tocopherol, commonly known as vitamin E. This water-soluble amphipathic formulation consists of d-alpha-tocopherol succinate coupled to polyethylene glycol (PEG) 1000 through a succinate linker. Its amphipathic nature enables the formation of micelles, facilitating uptake into enterocytes, even in the absence of bile salts. Upon hydrolysis, fat-soluble d-alpha-tocopherol is released. Tocofersolan significantly improves the absorption of d-alpha-tocopherol compared to free administration. Moreover, Tocofersolan acts as an inhibitor of P-glycoprotein (P-gp or MDR1) substrate-induced ATPase activity in cell-free assays. It has demonstrated efficacy against resistant K562 cells by binding to urokinase-type plasminogen activator, a crucial enzyme for cancer cell migration and invasion. Additionally, Tocofersolan inhibits tyrosine kinase, a key player in cancer cell development, offering potential applications in metabolomics and biochemical research. Its ability to enhance the absorption of water-insoluble agents and other fat-soluble vitamins positions it as a promising compound for formulation and drug delivery research. Application D-α-Tocopherol polyethylene glycol 1000 succinate has been used as an emulsifier in the preparation of Poly(lactic-co-glycolic acid) (PLGA) particle as synthetic DNA carriers by double emulsion (w1/o/w2) and nanoprecipitation method.[1] D-α-Tocopherol polyethylene glycol 1000 is a versatile compound that finds application in cell biology, metabolomics, biochemical and drug delivery research. Biochem/physiol Actions D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins.[2] TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.[1] Tocopherols (TCP) (vitamin E) are a series (α, α, α and α) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Tocopherol polyethylene glycol 1000 succinate (TPGS) may be used to create biodegradable polymers and antioxidant surfactants. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins.[2] TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.[1] Features and Benefits - Can be used in Metabolomics and Biochemical research - High-quality compound suitable for multiple research applications Other Notes For additional information on our range of Biochemicals, please complete this form. |
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