Methanol suitable for use as excipient EMPROVE® exp Ph Eur,BP,JPE,NF. Methanol CAS 67-56-1, chemical formula CH₃OH, molar mass 32.04 g/mol. Structural formula of Methanol (MeOH), MSDS, and description below.
Physicochemical Information
Boiling point
64.5 °C (1013 hPa)
Density
0.792 g/cm3 (20 °C)
Evaporation number
6.3
Explosion limit
5.5 - 44 %(V)
Flash point
10 °C
Ignition temperature
455 °C DIN 51794
Melting Point
-98 °C
Vapor pressure
128 hPa (20 °C)
Toxicological Information
LD 50 oral
LD50 Rat 5628 mg/kg
LD 50 dermal
LD50 Rabbit 17100 mg/kg
Safety Information according to GHS
Hazard Pictogram(s)
Hazard Statement(s)
H225: Highly flammable liquid and vapour. H301 + H311 + H331: Toxic if swallowed, in contact with skin or if inhaled. H370: Causes damage to organs.
Precautionary Statement(s)
P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P240: Ground/bond container and receiving equipment. P280: Wear protective gloves/ protective clothing. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P308 + P310: IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician. P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
RTECS
PC1400000
Storage class
3 Flammable liquids
WGK
WGK 1 slightly water endangering
Disposal
1 Strongly contaminated halogen-free organic solvents: container A.
Safety Information
Hazard Symbols
Flammable Toxic
Categories of danger
highly flammable, toxic
R Phrase
R 11-23/24/25-39/23/24/25 Highly flammable.Toxic by inhalation, in contact with skin and if swallowed.Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
S Phrase
S 7-16-36/37-45 Keep container tightly closed.Keep away from sources of ignition - No smoking.Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Storage
Storage temperature: no restrictions.
Transport Information
Declaration (railroad and road) ADR, RID
UN 1230 , 3 (6.1), II
Declaration (transport by air) IATA-DGR
UN 1230 , 3 (6.1), II
Declaration (transport by sea) IMDG-Code
UN 1230 , 3 (6.1), II
Specifications
Assay (GC)
≥ 99.5 %
Identity (IR)
conforms
Identity B (NF)
conforms
Identity (JPE)
conforms
Appearance
conforms
Clarity of solution
conforms
Acidity or alkalinity
conforms
Acidity
conforms
Alkalinity (as NH₃)
≤ 3 ppm
Refractive index (n 20/D)
1.328 - 1.330
Density (d 20 °C/20 °C)
0.791 - 0.793
Boiling range (64-65°C)
≥ 95 % (v/v)
Absorbance (at 230 nm)
≤ 0.150
Absorbance (at 250 nm)
≤ 0.050
Absorbance (at 270 nm)
≤ 0.020
Absorbance (at 290 nm)
≤ 0.010
The absorption curve is smooth
conforms
Benzene (impurity A) (GC)
≤ 2 ppm
Acetone (GC)
≤ 0.001 %
Ethanol (GC)
≤ 0.005 %
Ethanol (JPE)
conforms
Related substances (GC)
conforms
Residual solvents class 3 (ICH Q3C)
< 0.5
Other residual solvents (ICH Q3C)
excluded by manufacturing process
Heavy metals
conforms
Aldehydes and Acetone (as acetone)
≤ 0.003 %
Aldehyde and other foreign reducing substances
conforms
Reducing substances
conforms
Readily oxidizable substances
conforms
Readily carbonizable substances
conforms
Readily carbonizable substances (JPE)
conforms
Evaporation residue
≤ 0.0010 %
Water
≤ 0.10 %
Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present. Conforms to Ph Eur, BP, JPE, NF