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Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg

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Stok Kodu
LB.M.1082191000
Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg
Catalogue Number 108219
Synonyms Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
Description Tris(hydroxymethyl)aminomethane hydrochloride
Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT  
Product Information
CAS number 1185-53-1
EC number 214-684-5
Hill Formula C₄H₁₁NO₃˙ ClH
Chemical formula C₄H₁₁NO₃*ClH
Molar Mass 157.60 g/mol
HS Code 2922 19 00
Structure formula Image Structure formula Image
Quality Level MQ500
Physicochemical Information
Density 1.28 g/cm3 (20.2 °C)
Melting Point 150.7 °C
pH value 4.2 (100 g/l, H₂O, 20 °C)
Vapor pressure <0.1 hPa (50 °C)
Solubility 561 g/l soluble
Safety Information according to GHS
Storage class 10 - 13 Other liquids and solids
WGK WGK 1 slightly hazardous to water
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Storage and Shipping Information
Storage Store at +15 °C to +25 °C.
Specifications
Appearance (color) white to almost white
Appearance (description) crystalline powder
Assay (Perchloric acid titration, calc. on anhydrous substance) ≥ 99.0 %
Identity (IR-spectrum) conforms
pH-value (0.5 mol/l, water) 3.5 - 5.0
Melting range 147 - 153 °C
UV-Absorption (230 nm; 10 %; 1 cm; water) ≤ 0.1
UV-Absorption (260 nm; 10 %, 1 cm; water) ≤ 0.06
UV-Absorption (280 nm; 10 %; 1 cm; water) ≤ 0.06
UV-Absorption (300 nm; 10 %; 1 cm; water) ≤ 0.02
UV-Absorption (400 nm; 10 %; 1 cm; water) ≤ 0.01
As (Arsenic) ≤ 0.0001 %
Ca (Calcium) ≤ 0.0010 %
Cd (Cadmium) ≤ 0.0001 %
Cu (Copper) ≤ 0.0001 %
Fe (Iron) ≤ 0.0001 %
Mg (Magnesium) ≤ 0.0010 %
Ni (Nickel) ≤ 0.00025 %
Pb (Lead) ≤ 0.0001 %
Zn (Zinc) ≤ 0.0002 %
Residual solvents (ICHQ3C) of class 2 (Methanol) ≤ 3000 ppm
Residual solvents (ICHQ3C) of class 2 (Nitromethane) ≤ 50 ppm
Residual solvents (ICHQ3C) of class 3 (Ethanol) ≤ 5000 ppm
Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon) ≤ 5000 ppm
Other residual solvents (ICH Q3C) excluded by manufacturing process
Sulfated ash ≤ 0.03
Loss on Drying (105°C) ≤ 0.5
Water (according to Karl Fischer) ≤ 0.5
Endotoxins < 2.5
Total aerobic microbial count ≤ 10²
Total yeast and mould count ≤ 10²
Salmonella spp. absent in 10 g
E.coli absent in 1 g
Staphylococcus aureus absent in 1 g
Pseudomonas aeruginosa absent in 1 g
Candida albicans absent in 1 g
Bile tolerante gram negative bacteria absent in 1 g
DNases (Exo- and endonucleases) not detected
Proteases not detected
RNases not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
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Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg LB.M.1082191000
Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg

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