Sınırlı Stok
Sigma Aldrich 557324 Riluzole A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. 50 mg
Marka
Stok Kodu
LB.SA.557324-50MG
Kısa Bilgi
Synonym(s): Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124 Empirical Formula (Hill Notation): C8H5F3N2OS CAS Number: 1744-22-5 Molecular Weight: 234.20 MDL number: MFCD00210213 UNSPSC Code: 12352200 NACRES: NA.77
Bilgi
CAS Number: 1744-22-5
| Sigma Aldrich 557324 Riluzole 50 mg |
| Synonym(s): Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124 Empirical Formula (Hill Notation): C8H5F3N2OS CAS Number: 1744-22-5 Molecular Weight: 234.20 MDL number: MFCD00210213 UNSPSC Code: 12352200 NACRES: NA.77 |
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PROPERTIES
Quality Level 100
Assay ≥97% (HPLC) form solid manufacturer/tradename Calbiochem® storage condition OK to freeze, protect from light color white to off-white solubility HCl: 0.1 N, DMSO: 40 mg/mL cation traces heavy metals: ≤20 ppm shipped in ambient storage temp. 2-8°C InChI 1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) InChI key FTALBRSUTCGOEG-UHFFFAOYSA-N DESCRIPTION General description A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD). A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease). Biochem/physiol Actions Cell permeable: yes Primary Target Inhibits glutamate release and blocks Na+ channels Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Toxic (F) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400. Schiefer, J., et al. 2002. Mov. Disord.17, 748. Mizuta, I., et al. 2001. Neurosci. Lett.310, 117. Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196. Mizoule, J., et al. 1985. Neuropharmacology24, 767. Legal Information CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
