Sigma-Aldrich 8.55003 Rink Amide MBHA resin (100-200 mesh) 100 gr
Marka
Stok Kodu
LB.SA.8550030100
Kısa Bilgi
Synonym(s): 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucyl-MBHA resin (100-200 mesh), Rink Amide MBHA resin (100-200 mesh)
Bilgi
CAS Number: 431041-83-7
| Sigma-Aldrich 8.55003 Rink Amide MBHA resin (100-200 mesh) |
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Synonym(s): 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucyl-MBHA resin (100-200 mesh), Rink Amide MBHA resin (100-200 mesh)
CAS Number: 431041-83-7 UNSPSC Code: 12352111 NACRES: NA.22 |
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PROPERTIES
Quality Level 400 product line Novabiochem®
form beads
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename Novabiochem®
application(s) peptide synthesis functional group amine
storage temp. 2-30 °C
DESCRIPTION General description This support comprises the modified Rink amide linker attached via norleucine to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins Application Liquid chromatography-tandem mass spectrometry for forensic analysis: LSD-D₃ is utilized as an internal standard in the liquid chromatography-tandem mass spectrometry determination of LSD and its metabolites in forensic samples, enhancing accuracy and precision in the analytical results (Johansen and Jensen, 2005). Isotope dilution mass spectrometry in urine testing: Employed in the high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS) method, LSD-D₃ serves as a crucial internal standard for the quantification of lysergide (LSD) in urine, aiding in precise and accurate drug testing (White et al., 1999). Automated extraction and LC/MS/MS confirmation: LSD-D₃ is used in the automated extraction of lysergic acid diethylamide from various biological matrices, followed by confirmation using LC/MS/MS. This application highlights its role in improving the efficiency and reliability of toxicological analyses (de Kanel et al., 1998). Linkage Replaces: 01-64-0037 Analysis Note Colour (visual): white to light yellow to beige Appearance of substance (visual): beads Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.90 mmol/g TNBS-Test: passes test Swelling Volume (in DMF): lot specific result Swelling Volume (in CH₂Cl₂): lot specific result Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh. Legal Information Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany |
