Sigma Aldrich A6636 Aflatoxin B1 from Aspergillus flavus from Aspergillus flavus 10 mg
Marka
Stok Kodu
LB.SA.A6636-10MG
Kısa Bilgi
Empirical Formula (Hill Notation): C17H12O6 CAS Number: 1162-65-8 Molecular Weight: 312.27 Beilstein: 1269174 EC Number: 214-603-3 MDL number: MFCD00869647 PubChem Substance ID: 24891116 NACRES: NA.77
| Sigma Aldrich A6636 Aflatoxin B1 from Aspergillus flavus from Aspergillus flavus 10 mg |
|
Empirical Formula (Hill Notation): C17H12O6
CAS Number: 1162-65-8
Molecular Weight: 312.27
Beilstein: 1269174
EC Number: 214-603-3
MDL number: MFCD00869647
PubChem Substance ID: 24891116
NACRES: NA.77 |
|
PROPERTIES
biological source Aspergillus flavus
Quality Level 300
Assay ≥98.0% (HPLC)
form powder
greener alternative product score
old score: 51
new score: 42
Find out more about DOZN™ Scoring
greener alternative product characteristics
Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
greener alternative category Re-engineered
storage temp. 2-8°C
SMILES string COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14
InChI 1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
InChI key OQIQSTLJSLGHID-WNWIJWBNSA-N
DESCRIPTION
General description
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Waste Prevention”, "Designing Safer Chemicals” and "Design for Energy Efficiency”. Click here to view its DOZN scorecard.
Application
Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.
Biochem/physiol Actions
Aflatoxin B1 is a carcinogenic compound produced by Aspergillus flavus, a common soil fungus, that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 is a food contaminant and a hepatocarcinogen. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR). Aflatoxin B1 is a CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate.
Warning
Possibly carcinogenic. |
