Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 10 mg
Marka
Stok Kodu
LB.SA.A9809-10MG
Kısa Bilgi
Synonym(s): 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA Empirical Formula (Hill Notation): C21H19N3O3S · HCl CAS Number: 54301-15-4 Molecular Weight: 429.92 MDL number: MFCD07799963 PubChem Substance ID: 24278248 NACRES: NA.77
Bilgi
CAS Number: 54301-15-4
| Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 10 mg |
| Synonym(s): 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA Empirical Formula (Hill Notation): C21H19N3O3S · HCl CAS Number: 54301-15-4 Molecular Weight: 429.92 MDL number: MFCD07799963 PubChem Substance ID: 24278248 NACRES: NA.77 |
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PROPERTIES
Quality Level 200
Assay ≥98% (TLC) form powder color red to brown mp 197-199 °C (lit.) solubility DMSO: 10 mg/mL (with heat and sonication), 30% ethanol: 4 mg/mL storage temp. room temp SMILES string Cl.COc1cc(NS(C)(=O)=O)ccc1Nc2c3ccccc3nc4ccccc24 InChI 1S/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H InChI key WDISRLXRMMTXEV-UHFFFAOYSA-N Gene Information human ... TOP2A(7153) , TOP2B(7155) DESCRIPTION Application Amsacrine hydrochloride has been used: - as a topoisomerase poison in bacteriophage T4 topoisomerase assay[1] - as a topoisomerase inhibitor in Drosophila cell line, Kc167 [2] - as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts[3] -as a topoisomerase II poison in dose-response assays in C elegans[4] Biochem/physiol Actions Amsacrine (m-AMSA) is a derivative of acridine[5] and an antileukemia drug.[3] It is an anticancer drug with antineoplastic activity that targets topoisomerase II.[5] AMSA is an apoptosis inducer[6] and favors the accumulation of double-stranded breaks (DSBs).[2] It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.[6] Amsacrine hydrochloride is a DNA topoisomerase II inhibitor. |
