Sigma-Aldrich AG723-M C-Reactive Protein 1 mg
Marka
Stok Kodu
LB.SA.AG723
Kısa Bilgi
Synonym(s): CRP UNSPSC Code: 12352202 eCl@ss: 32160405 NACRES: NA.41
| Sigma-Aldrich AG723-M C-Reactive Protein 1 mg |
| Synonym(s): CRP UNSPSC Code: 12352202 eCl@ss: 32160405 NACRES: NA.41 |
|
PROPERTIES
biological source human
Quality Level 100 300 Assay >98% (SDS-PAGE) form liquid manufacturer/tradename Chemicon® concentration 3.5 mg/mL NCBI accession no. NM_000567.2 UniProt accession no. P02741 DESCRIPTION General description C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.[1] Application C-reactive protein (CRP) has been used: - as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)[2] - to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation[3] - to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response[4] Biochem/physiol Actions C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.[4] Quality No precipitin bands when tested at 2 mg/mL against anti-whole human serum. Physical form Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl2 Storage and Stability Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid. Legal Information CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |