Sigma-Aldrich B1378 2,6-Di-tert-butyl-4-methylphenol ≥99.0% (GC), powder 1 kg
Marka
Stok Kodu
LB.SA.B1378-1KG
Kısa Bilgi
Synonym(s): 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC Linear Formula: [(CH3)3C]2C6H2(CH3)OH CAS Number: 128-37-0 Molecular Weight: 220.35 Beilstein: 1911640 EC Number: 204-881-4 MDL number: MFCD00011644 PubChem Substance ID: 57653920 NACRES: NA.22
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Sigma-Aldrich B1378 2,6-Di-tert-butyl-4-methylphenol ≥99.0% (GC), powder 1 kg |
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Synonym(s): 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC
Linear Formula: [(CH3)3C]2C6H2(CH3)OH
CAS Number: 128-37-0
Molecular Weight: 220.35
Beilstein: 1911640
EC Number: 204-881-4
MDL number: MFCD00011644
PubChem Substance ID: 57653920
NACRES: NA.22 |
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PROPERTIES
vapor density 7.6 (vs air)
Quality Level 200
vapor pressure <0.01 mmHg ( 20 °C)
Assay ≥99.0% (GC)
form powder
autoignition temp. 878 °F bp 265 °C (lit.)
mp 69-73 °C (lit.)
solubility ethanol: 100 mg/mL, vegetable oils: soluble
SMILES string Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C InChI 1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChI key NLZUEZXRPGMBCV-UHFFFAOYSA-N
Gene Information human ... CAPN1(823) rat ... Capn1(29153) , Nos1(24598)
DESCRIPTION
Packaging
100, 500 g in poly bottle
1 kg in poly bottle
Biochem/physiol Actions
Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1. |
