Sigma-Aldrich C3045 Cholesterol powder, BioReagent, suitable for cell culture, ≥99% 100 gr
Marka
Stok Kodu
LB.SA.C3045-100G
Kısa Bilgi
Synonym(s): 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol Empirical Formula (Hill Notation): C27H46O CAS Number: 57-88-5 Molecular Weight: 386.65 Beilstein: 1915888 EC Number: 200-353-2 MDL number: MFCD00003646
Bilgi
CAS Number: 57-88-5
| Sigma-Aldrich C3045 Cholesterol powder, BioReagent, suitable for cell culture, ≥99% 100 gr |
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Synonym(s): 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
Empirical Formula (Hill Notation): C27H46O
CAS Number: 57-88-5
Molecular Weight: 386.65
Beilstein: 1915888
EC Number: 200-353-2
MDL number: MFCD00003646
eCl@ss: 39023139
PubChem Substance ID: 24892329
NACRES: NA.75
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PROPERTIES
biological source ovine wool
Quality Level 200
product line BioReagent
assay ≥99%
form powder
technique(s) cell culture | mammalian: suitable
bp 360 °C (lit.)
mp 147-149 °C (lit.)
solubility
H2O: 0.002 mg/mL
Tween: soluble
ethanol: soluble
serum: soluble
density 1.067 g/mL at 25 °C (lit.)
shipped in ambient
storage temp. −20°C
SMILES string CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key HVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Information human... POLA1(5422), TOP2A(7153) rat... Ar(24208), Polb(29240)
DESCRIPTION
General description
Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals[1] and coordinates endocytosis.[2] It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia.[2] Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease.[1] Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development.[3] High cholesterol levels favor breast cancer progression.[4]
Application
Cholesterol has been used: as a medium supplement in chorionic villous tissue culture form placenta[5] as a component of hormone pellet for implantation in mice ovary[6] for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1[7]
Packaging
5, 25, 100 g in poly bottle
Biochem/physiol
Actions Major component of all biological membranes; ~25% of total brain lipid is cholesterol.
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