Sigma-Aldrich C80105 Chrysin 97% 25 gr
Kategori
Marka
Stok Kodu
LB.SA.C80105-25G
Kısa Bilgi
Synonym(s): 5,7-Dihydroxyflavone Empirical Formula (Hill Notation): C15H10O4 CAS Number: 480-40-0 Molecular Weight: 254.24 Beilstein: 233276 EC Number: 207-549-7 MDL number: MFCD00006834 PubChem Substance ID: 24893009 NACRES: NA.47
| Sigma-Aldrich C80105 Chrysin 97% 25 gr |
|
Synonym(s): 5,7-Dihydroxyflavone
Empirical Formula (Hill Notation): C15H10O4
CAS Number: 480-40-0
Molecular Weight: 254.24
Beilstein: 233276
EC Number: 207-549-7
MDL number: MFCD00006834
PubChem Substance ID: 24893009
NACRES: NA.47 |
|
PROPERTIES
Quality Level 100
assay 97%
form powder
mp 284-286 °C (lit.)
solubility 0.1 M NaOH: 0.008 g/L
λmax 348 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp. room temp
SMILES string Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3
InChI 1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
InChI key RTIXKCRFFJGDFG-UHFFFAOYSA-N
Gene Information human... CDC2(983), CDK5(1020), CDK6(1021), CYP19A1(1588), CYP1A2(1544), GSK3A(2931) mous ... Hexa(15211), Ptgs2(19225) rat... Gabra2(29706)
DESCRIPTION
Application
-Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.[1]
-It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.[2]
-It has been used to study the effect of chrysin on human ovarian cancer cells.[3]
Biochem/physiol Actions
Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity.[4] Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.[5] |
