Sigma Aldrich D9035 Diazoxide 1 gr
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Stok Kodu
LB.SA.D9035-1G
Kısa Bilgi
Synonym(s): 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Empirical Formula (Hill Notation): C8H7ClN2O2S CAS Number: 364-98-7 Molecular Weight: 230.67 EC Number: 206-668-1 MDL number: MFCD00078578 PubChem Substance ID: 24277831 NACRES: NA.77
| Sigma Aldrich D9035 Diazoxide 1 gr |
| Synonym(s): 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Empirical Formula (Hill Notation): C8H7ClN2O2S CAS Number: 364-98-7 Molecular Weight: 230.67 EC Number: 206-668-1 MDL number: MFCD00078578 PubChem Substance ID: 24277831 NACRES: NA.77 |
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PROPERTIES
form powder
Quality Level 100 solubility 0.1 M NaOH: soluble H2O: insoluble methanol: soluble originator Schering Plough SMILES string CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 InChI 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) InChI key GDLBFKVLRPITMI-UHFFFAOYSA-N Gene Information human ... KCNA1(3736) , KCNJ11(3767) , KCNJ8(3764) , KCNMA1(3778) mouse ... Kcnj1(56379) , Kcnj11(16514) rat ... Gria1(50592) , Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj8(25472) DESCRIPTION
General description
Diazoxide is a nondiuretic benzothiadiazine,[1] which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell KATP channel opener. Diazoxide prevents the secretion of insulin.[2] Application Diazoxide has been used for diazoxide infusion.[3][4] It has also been used to prevent depolarization for K+-induced exocytosis.[5] Biochem/physiol Actions Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive. Features and Benefits This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates. |
