Sigma Aldrich D9533 Deferoxamine mesylate salt ≥92.5% (TLC), powder, iron-chelating agent CAS No.: 138-14-7 1 gr
Marka
Stok Kodu
LB.SA.D9533-1G
Kısa Bilgi
Synonym(s): DFX mesylate, DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt Empirical Formula (Hill Notation): C25H48N6O8 · CH4O3S CAS Number: 138-14-7 Molecular Weight: 656.79 EC Number: 205-314-3 MDL number: MFCD00058605 UNSPSC Code: 12352116 PubChem Substance ID: 24894304 NACRES: NA.32
Bilgi
CAS Number: 138-14-7
| Sigma Aldrich D9533 Deferoxamine mesylate salt ≥92.5% (TLC), CAS No.: 138-14-7 |
| Synonym(s): DFX mesylate, DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt Empirical Formula (Hill Notation): C25H48N6O8 · CH4O3S CAS Number: 138-14-7 Molecular Weight: 656.79 EC Number: 205-314-3 MDL number: MFCD00058605 UNSPSC Code: 12352116 PubChem Substance ID: 24894304 NACRES: NA.32 |
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PROPERTIES
Product Name Deferoxamine mesylate salt, powder, ≥92.5% (TLC)
Quality Level 200 Assay ≥92.5% (TLC) form powder color white to off-white solubility H2O: 50 mg/mL storage temp. −20°C SMILES string CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN InChI 1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4) InChI key IDDIJAWJANBQLJ-UHFFFAOYSA-N DESCRIPTION Application Deferoxamine mesylate salt has been used - for cell pretreatment to assess its influenceon cell viability and its interactions with other compounds ([1]) - to study the effect on Lipocalin 2(Lcn2) production triggered by amyloid-β(Aβ). ([2]) - used to induce iron starvation in bacterial cultures.([3]) Biochem/physiol Actions An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage. Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. |
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