Sigma-Aldrich ED2SS Ethylenediaminetetraacetic acid disodium salt dihydrate reagent grade, 98.5-101.5% (titration) 250 gr
Marka
Stok Kodu
LB.SA.ED2SS-250G
Kısa Bilgi
Synonym(s): Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2 Empirical Formula (Hill Notation): C10H14N2Na2O8 · 2H2O CAS Number: 6381-92-6 Molecular Weight: 372.24 Beilstein: 3900609 EC Number: 205-358-3 PubChem Substance ID: 24894708 NACRES: NA.77
| Sigma-Aldrich ED2SS Ethylenediaminetetraacetic acid disodium salt dihydrate |
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Synonym(s): Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2
Empirical Formula (Hill Notation): C10H14N2Na2O8 · 2H2O
CAS Number: 6381-92-6
Molecular Weight: 372.24
Beilstein: 3900609
EC Number: 205-358-3
PubChem Substance ID: 24894708
NACRES: NA.77
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PROPERTIES
biological source synthetic (organic)
Quality Level 200
grade reagent grade
assay 98.5-101.5% (titration)
form powder
mp 248 °C (dec.) (lit.)
solubility H2O: soluble, clear, colorless
storage temp. room temp
SMILESstring O.O.O.O.Na+].Na+].Na+].Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])
=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
InChI 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
InChI key OVBJJZOQPCKUOR-UHFFFAOYSA-L
DESCRIPTION
General description
Ethylenediaminetetraacetic acid (EDTA) is an aminopolycarboxylic acid and a hexadentate ligand. It chelates with metal ions to form an octahedral complex especially with cations.[1] Ethylenediaminetetraacetic acid disodium salt (EDTA) is a blood anticoagulant and contributes to the pathogenesis of pseudothrombocytopenia. It chelates with calcium in the blood and inhibits clotting and is routinely used in haematological tests.[2] It enhances the antibacterial activity of lysozyme.[3] EDTA used in chelation therapy chelates with calcium and favors dilation of artery, solubilisation of atheromatous plaques in atherosclerotic vascular disease.[4] EDTA chelation therapy protects from lipid peroxidation events in liver fibrosis.[5] Application
Ethylenediaminetetraacetic acid disodium salt dihydrate has been used as a component of the plasma membrane resuspension buffer,[6] inhibitor′s preservative solution (IS)[7] and luciferase activity assay mix.[8] Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Packaging
50, 100, 250, 500 g in poly bottle
1 kg in poly bottle
2.5, 5 kg in poly drum
Biochem/physiol Actions
Zinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases. |
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