Sigma-Aldrich F3385 Fetuin from fetal bovine serum lyophilized powder, BioReagent, suitable for cell culture CAS No.: 9014-81-7 100 mg
Marka
Stok Kodu
LB.SA.F3385-100MG
Kısa Bilgi
Synonym(s): Fetuin from fetal calf serum CAS Number: 9014-81-7 EC Number: 232-762-7 MDL number: MFCD00131055 UNSPSC Code: 12352202 NACRES: NA.75
| Sigma-Aldrich F3385 Fetuin from fetal bovine serum CAS No.: 9014-81-7 |
| Synonym(s): Fetuin from fetal calf serum CAS Number: 9014-81-7 EC Number: 232-762-7 MDL number: MFCD00131055 UNSPSC Code: 12352202 NACRES: NA.75 |
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PROPERTIES
product line BioReagent
Quality Level 200 form lyophilized powder mol wt 48.4 kDa technique(s) cell culture | mammalian: suitable impurities ≤0.3% free N-acetylneuraminic acid solubility H2O: 1 mg/mL storage temp. 2-8°C DESCRIPTION General description Fetuin from fetal bovine serum is a plasma glycoprotein.[1] It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue.[2] A glycoprotein derived from FBS that is used as Fetuin has been used at a concentration of 500 mg/ml to supplement serum free F12 medium (along with insulin, transferrin and 2-mercaptoethanol) in culture of embryonal carcinoma cells. Application Fetuin from fetal bovine serum has been used: - as a substrate to determine neuraminidase activity[3] - to validate the specificity of sialidases[4] - to stabilize m-calpain[5] Biochem/physiol Actions Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism.[6] Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases.[7] Fetuin exhibits anti-inflammatory property.[2] Preparation Note Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947). |