Sigma-Aldrich H5653 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) 5 mg
Kategori
Marka
Stok Kodu
LB.SA.H5653-5MG
Kısa Bilgi
Synonym(s): 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG Empirical Formula (Hill Notation): C10H13N5O5 CAS Number: 88847-89-6 Molecular Weight: 283.24 MDL number: MFCD00210311 PubChem Substance ID: 24895702 NACRES: NA.77
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Sigma-Aldrich H5653 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) 5 mg |
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Synonym(s): 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
Empirical Formula (Hill Notation): C10H13N5O5
CAS Number: 88847-89-6
Molecular Weight: 283.24
MDL number: MFCD00210311
PubChem Substance ID: 24895702
NACRES: NA.77
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PROPERTIES
Quality Level 200
assay ≥98% (TLC)
storage temp. 2-8°C
SMILES string O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1
InChI 1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)
InChI key HCAJQHYUCKICQH-UHFFFAOYSA-N
DESCRIPTION
Application
8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection[1]
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement[2]
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo[3]
- as a standard for LC/MS/MS analysis[4]
Packaging
1, 5 mg in glass bottle
Biochem/physiol
Actions A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer.[5] Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).[6] |
