Sigma Aldrich H6525 Hemoglobin from bovine blood suitable for protease substrate, substrate powder CAS No.: 9008-02-0 25 gr
Marka
Stok Kodu
LB.SA.H2625-25G
Kısa Bilgi
Synonym(s): Bovine hemoglobin, Hb, Methemoglobin CAS Number: 9008-02-0 MDL number: MFCD00131282 UNSPSC Code: 12352202 eCl@ss: 42030116 NACRES: NA.61
Bilgi
CAS Number: 9008-02-0
| Sigma Aldrich H6525 Hemoglobin from bovine blood suitable for protease substrate, substrate powder |
| Synonym(s): Bovine hemoglobin, Hb, Methemoglobin CAS Number: 9008-02-0 MDL number: MFCD00131282 UNSPSC Code: 12352202 eCl@ss: 42030116 NACRES: NA.61 |
|
PROPERTIES
biological source bovine blood
Quality Level 300 form substrate powder mol wt Mr ~64500 technique(s) activity assay: suitable solubility H2O: soluble 20 mg/mL suitability suitable for protease substrate UniProt accession no. P01966 P02070 P02081 P06642 P06643 storage temp. 2-8°C DESCRIPTION General description Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%.[1] Hemoglobin is a globular protein with α and β chains with every 141 and 146 amino acids respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme.[2] Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide. Application Hemoglobin from bovine blood has been used as a substrate in cathepsin D activity assay.[3][4] It has also been used to measure the activity of acid proteases (pepsin-like) in the stomach extract.[5] The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials. Biochem/physiol Actions Bovine hemoglobin is used in the production of hemoglobin-vesicles (HbV). It has high thermal stability and high oxygen affinity when compared to human hemoglobin.[6] Bovine hemoglobin interacts with synthetic and azo dyes.[2] Polymerized forms of bovine hemoglobin are used to treat autoimmune hemolytic anemia.[7] Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues. Caution Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin. Preparation Note Prepared from washed, lysed and dialyzed erythrocytes. |
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