Sigma-Aldrich M4145 Minoxidil ≥99% (TLC) 500 mg
| Sigma-Aldrich M4145 Minoxidil ≥99% (TLC) 500 mg |
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Synonym(s): 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
Empirical Formula (Hill Notation): C9H15N5O
CAS Number: 38304-91-5
Molecular Weight: 209.25
EC Number: 253-874-2
MDL number: MFCD00063409
PubChem Substance ID: 24277853
NACRES: NA.77
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PROPERTIES
Quality Level 100
assay ≥99% (TLC)
mp 272-274 °C (dec.) (lit.)
originator Johnson & Johnson
SMILES string NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Gene Information human... KCNJ1(3758)
DESCRIPTION
Application
Minoxidil has been used as test drug:
in dermal papilla spheroid model, to study the effect of hair regeneration
administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses
Biochem/physiol Actions
Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia. Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth. |