Sigma-Aldrich N1876 Neomycin trisulfate salt hydrate powder 25 gr
Marka
Stok Kodu
LB.SA.N1876-25G
Kısa Bilgi
Synonym(s): Framycetin sulfate Empirical Formula (Hill Notation): C23H46N6O13 · 3H2SO4 · xH2O CAS Number: 1405-10-3 Molecular Weight: 908.88 (anhydrous basis) EC Number: 215-773-1 PubChem Substance ID: 57654443 NACRES: NA.85
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Sigma-Aldrich N1876 Neomycin trisulfate salt hydrate powder 25 gr |
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Synonym(s): Framycetin sulfate
Empirical Formula (Hill Notation): C23H46N6O13 · 3H2SO4 · xH2O
CAS Number: 1405-10-3
Molecular Weight: 908.88 (anhydrous basis)
EC Number: 215-773-1
PubChem Substance ID: 57654443
NACRES: NA.85
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PROPERTIES
form powder
Quality Level 200
solubility H2O: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action protein synthesis | interferes
SMILES string O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O
InChI 1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1
InChI key WHAGUNPVKDUVFV-QGTTWHFQSA-N
DESCRIPTION
General description
Chemical structure: aminoglycoside
Application
Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells that have been transformed using the selectable marker gene (neo), and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins.[1][2][3].
Packaging
25, 100 g in glass bottle
Biochem/physiol Actions
Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria.
Caution
Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
Preparation Note
Neomycin sulfate is soluble in H2O at 50 mg/mL, yielding a clear solution.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place |
