Sigma-Aldrich Q4951 Quercetin ≥95% (HPLC), solid, flavonoid antioxidant CAS No.: 117-39-5 10 gr
Marka
Stok Kodu
LB.SA.Q4951-10G
Kısa Bilgi
Synonym(s): 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3′,4′,5,6-Pentahydroxyflavone Empirical Formula (Hill Notation): C15H10O7 CAS Number: 117-39-5 Molecular Weight: 302.24 Beilstein: 317313 EC Number: 204-187-1 UNSPSC Code: 12352207 PubChem Substance ID: 329823865 NACRES: NA.77
| Sigma-Aldrich Q4951 Quercetin ≥95% (HPLC), solid, flavonoid antioxidant CAS No.: 117-39-5 10 gr |
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Synonym(s): 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 3,3′,4′,5,6-Pentahydroxyflavone
Empirical Formula (Hill Notation): C15H10O7
CAS Number: 117-39-5 Molecular Weight: 302.24 Beilstein: 317313 EC Number: 204-187-1 UNSPSC Code: 12352207 PubChem Substance ID: 329823865 NACRES: NA.77 |
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PROPERTIES
Product Name Quercetin, ≥95% (HPLC), solid
biological source synthetic (organic) Assay ≥95% (HPLC) form solid mp 316.5 °C solubility water: practically insoluble storage temp. room temp SMILES string OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1 InChI 1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H InChI key REFJWTPEDVJJIY-UHFFFAOYSA-N DESCRIPTION Quercetin is a polyphenolic flavonoid, found in food including onions, asparagus, buckwheat, radish leaves, green tea, cranberry, broccoli, apple, blueberry, and coriander. Quercetin shows strong intramolecular H-binding, which contributes to the bioavailability and transport of the compound. This explains the biological multi-functional nature of the compound and allows for the formation of strong complexes, frequently with metals.[1] Quercetin inhibits cellular proliferation and minimizes DNA damage. Among its many cardiovascular protection properties, quercetin has antioxidant and antiplatelet properties as well as antiplatelet and anti-muscle cell proliferation and migration. It also enhances cardiac cell mitochondrial function and inhibits NF-κB. Numerous animal studies involving dietary quercetin supplementation have shown a protective effect against cardiac problems.[2] Application - Quercetin has been used as an antioxidant which reversed the immunosuppressive effects of high glucose and hyperglycemic sera in type 2 diabetic patients.[3] - It has been used as a detoxifying phytochemical in Apis mellifera.[4] - It has been used as a positive control in DPPH (2,2- diphenyl-1-picryhydrazyl) radical scavenging assay. It has also been used for the preparation of calibration curve to determine total flavonoid content.[5] Biochem/physiol Actions Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity. Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin may also inhibit fatty acid synthase activity. Preparation Note This chemical is soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml). |
