Sigma-Aldrich S3256 Spermine ≥97% 5 gr
Marka
Stok Kodu
LB.SA.S3256-5G
Kısa Bilgi
Synonym(s): N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2 CAS Number: 71-44-3 Molecular Weight: 202.34 Beilstein: 1750791 EC Number: 200-754-2 MDL number: MFCD00008215 PubChem Substance ID: 24899550 NACRES: NA.25
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Sigma-Aldrich S3256 Spermine ≥97% 5 gr |
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Synonym(s): N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2
CAS Number: 71-44-3
Molecular Weight: 202.34
Beilstein: 1750791
EC Number: 200-754-2
MDL number: MFCD00008215
PubChem Substance ID: 24899550
NACRES: NA.25
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PROPERTIES
biological source microbial synthetic
Quality Level 200
description form: solid or semisolid
assay ≥97%
bp 150 °C/5 mmHg (lit.)
mp 28-30 (lit.)
solubility water: 50 mg/mL, clear, colorless
storage temp. 2-8°C
SMILES string [H]N(CCCN)CCCCN([H])CCCN
InChI 1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChI key PFNFFQXMRSDOHW-UHFFFAOYSA-N
Gene Information human ... GRIN2B(2904) rat ... Grin2a(24409)
DESCRIPTION
General description
Spermine is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.[1]
Application
Spermine has been used:
as an inositol 1,4,5-trisphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) agonist to activate MCU in mouse podocytes[2]
in the biolistic transfection of filarial parasites[3]
for the production of adeno-associated virus (AAV)[4]
Packaging
1, 5, 25 g in glass bottle
Biochem/physiol
Actions Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
