Sigma-Aldrich SML3182 Eltrombopag ≥98% (HPLC) 10 mg
Marka
Stok Kodu
LB.SA.SML3182-10MG
Kısa Bilgi
Synonym(s): (Z)-3′-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylic acid, 3′-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid, SB 497115, SB-497115, SB497115 Empirical Formula (Hill Notation): C25H22N4O4 CAS Number: 496775-61-2 Molecular Weight: 442.47 MDL number: MFCD20926253
Garanti Süresi
24 Ay
| Sigma-Aldrich SML3182 Eltrombopag ≥98% (HPLC) 10 mg |
|
Synonym(s): (Z)-3′-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylic acid, 3′-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid, SB 497115, SB-497115, SB497115
Empirical Formula (Hill Notation): C25H22N4O4
CAS Number: 496775-61-2
Molecular Weight: 442.47
MDL number: MFCD20926253 |
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PROPERTIES
Quality Level 100
Assay ≥98% (HPLC)
form powder
color faint yellow to dark orange
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
SMILES string OC1=C(C=CC=C1N/N=C2C(C)=NN(C/2=O)C3=CC(C)=C(C=C3)C)C4=CC=CC(C(O)=O)=C4
DESCRIPTION
Biochem/physiol Actions
Eltrombopag is an orally active nonpeptide thrombopoietin receptor (TpoR) agonist that selectively induces STAT activation and proliferation (EC50 = 270 & 30 nM, respectively) of hToR-transfected, but not non-transfected, BAF3 cells. Eltrombopag increases the differentiation of primary human CD34(+) bone marrow cells into CD41(+) megakaryocytes ex vivo (EC50 = 100 nM) and exhibits thrombopoietic activity in chimpanzees in vivo (10 mg/kg/day p.o.). |
