Sigma-Aldrich T2577 Temozolomide ≥98% (HPLC) 25 mg
Marka
Stok Kodu
LB.SA.T2577-25MG
Kısa Bilgi
Synonym(s): 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, NSC 362856 Empirical Formula (Hill Notation): C6H6N6O2 CAS Number: 85622-93-1 Molecular Weight: 194.15 MDL number: MFCD00866492 PubChem Substance ID: 329826714 NACRES: NA.77
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Sigma-Aldrich T2577 Temozolomide ≥98% (HPLC) 25 mg |
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Synonym(s): 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, NSC 362856
Empirical Formula (Hill Notation): C6H6N6O2
CAS Number: 85622-93-1
Molecular Weight: 194.15
MDL number: MFCD00866492
PubChem Substance ID: 329826714
NACRES: NA.77 |
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PROPERTIES
Assay ≥98% (HPLC)
form powder
color white to light brown
solubility DMSO: 10 mg/mL, clear, H2O: insoluble
originator Schering Plough
storage temp. 2-8°C
SMILES string CN1N=Nc2c(ncn2C1=O)C(N)=O
InChI 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key BPEGJWRSRHCHSN-UHFFFAOYSA-N
DESCRIPTION
Application
Temozolomide has been used for analyzing drug resistance mechanisms in glioblastoma cell lines15,16. Biochem/physiol Actions Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates.
Preparation Note
Temozolomide is soluble in DMSO at a concentration that is greater than 20 mg/ml. It is insoluble in water. |
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