Sigma-Aldrich C7017 Choline chloride ≥99% 10 mg
Marka
Stok Kodu
LB.SA.C7017-10MG
Kısa Bilgi
Synonym(s): (2-Hydroxyethyl)trimethylammonium chloride Linear Formula: (CH3)3N(Cl)CH2CH2OH CAS Number: 67-48-1 Molecular Weight: 139.62 Beilstein: 3563126 EC Number: 200-655-4 MDL number: MFCD00011721 PubChem Substance ID: 57654039 NACRES: NA.25
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Sigma-Aldrich C7017 Choline chloride ≥99% 10 mg |
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Synonym(s): (2-Hydroxyethyl)trimethylammonium chloride
Linear Formula: (CH3)3N(Cl)CH2CH2OH
CAS Number: 67-48-1
Molecular Weight: 139.62
Beilstein: 3563126
EC Number: 200-655-4
MDL number: MFCD00011721
PubChem Substance ID: 57654039
NACRES: NA.25 |
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PROPERTIES
biological source synthetic
Assay ≥99%
form powder
color white
mp 302-305 °C (dec.) (lit.)
lipid type phospholipids
SMILES string [Cl-].C[N+](C)(C)CCO
InChI 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
InChI key SGMZJAMFUVOLNK-UHFFFAOYSA-M
DESCRIPTION
General description
Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver.[1] It maintains cell structural integrity and cell signalling.[2] Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.[3]
Application
Choline chloride has been used:
- in choline release assay[4]
- as an endogenous agonist of sigma-1 receptors (Sig-1Rs)[5]
- as a standard to analyse interrelationships between methionine and choline metabolism[6]
Biochem/physiol Actions
Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes.
Substrates
Choline acetyltransferase substrate |
