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Sigma-Aldrich M2307 Mucin from porcine stomach Type II 100 gr

Stok Kodu
LB.SA.M2307-100G
Kısa Bilgi
Synonym(s): MUC CAS Number: 84082-64-4 EC Number: 282-010-7 MDL number: MFCD00131629 NACRES: NA.61
Ön Siparişli Ürün
Sigma-Aldrich M2307 Mucin from porcine stomach Type II 100 gr 
Synonym(s): MUC
CAS Number:
84082-64-4
EC Number:
282-010-7
MDL number:
MFCD00131629
NACRES:
NA.61
Sigma-Aldrich M2307 Mucin from porcine stomach Type II  
PROPERTIES
biological source Porcine stomach
Quality Level
200
type
Type II
form
powder
composition
bound sialic acid, ≤1.2%
technique(s)
cell culture | mammalian: suitable
solubility
1 M NaOH: soluble 20 mg/mL
UniProt accession no.
A0A5G2QSD1
storage temp.
2-8°C
Gene Information
pig ... MUC2(100127145)
 
DESCRIPTION
General description
Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation.[1] The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains.[2] Mucins are classified into secreted and transmembrane mucins.[3] Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus.[4] It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.[5]
Application
Mucin from porcine stomach has been used:
in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice[6] as a component of digestion fluid solutions in in vitro human digestion model[7] as a component of simulated saliva fluid[8] Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.[9]
Biochem/physiol Actions
Mucin has wide pharmacological applications in drug delivery.[1] Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.[3] Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.[10]
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Sigma-Aldrich M2307 Mucin from porcine stomach Type II
Sigma-Aldrich M2307 Mucin from porcine stomach Type II 100 gr Synonym(s): MUC, CAS Number: 84082-64-4, EC Number: 282-010-7, MDL number: MFCD00131629, NACRES: NA.61 LB.SA.M2307-100G
Sigma-Aldrich M2307 Mucin from porcine stomach Type II 100 gr

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