Sigma-Aldrich M2307 Mucin from porcine stomach Type II 500 gr
Marka
Stok Kodu
LB.SA.M2307-500G
Kısa Bilgi
Synonym(s): MUC CAS Number: 84082-64-4 EC Number: 282-010-7 MDL number: MFCD00131629 NACRES: NA.61
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Sigma-Aldrich M2307 Mucin from porcine stomach Type II 500 gr
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| Synonym(s): MUC CAS Number: 84082-64-4 EC Number: 282-010-7 MDL number: MFCD00131629 NACRES: NA.61 |
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PROPERTIES
biological source Porcine stomach
Quality Level 200 type Type II form powder composition bound sialic acid, ≤1.2% technique(s) cell culture | mammalian: suitable solubility 1 M NaOH: soluble 20 mg/mL UniProt accession no. A0A5G2QSD1 storage temp. 2-8°C Gene Information pig ... MUC2(100127145) DESCRIPTION
General description
Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation.[1] The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains.[2] Mucins are classified into secreted and transmembrane mucins.[3] Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus.[4] It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.[5] Application Mucin from porcine stomach has been used: in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice[6] as a component of digestion fluid solutions in in vitro human digestion model[7] as a component of simulated saliva fluid[8] Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.[9] Biochem/physiol Actions Mucin has wide pharmacological applications in drug delivery.[1] Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.[3] Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.[10] |
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