Sigma-Aldrich PHR1237 Cholecalciferol (Vitamin D3) Pharmaceutical Secondary Standard; Certified Reference Material 500 mg
Kategori
Marka
Stok Kodu
LB.SA.PHR1237-500MG
Kısa Bilgi
Synonym(s): Cholecalciferol, (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol Empirical Formula (Hill Notation): C27H44O CAS Number: 67-97-0 Molecular Weight: 384.64 Beilstein: 2339331 EC Number: 200-673-2 MDL number: MFCD00078131 PubChem Substance ID: 329823242 NACRES: NA.24
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Sigma-Aldrich PHR1237 Cholecalciferol (Vitamin D3) 500 mg |
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Synonym(s): Cholecalciferol, (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
Empirical Formula (Hill Notation): C27H44O
CAS Number: 67-97-0
Molecular Weight: 384.64
Beilstein: 2339331
EC Number: 200-673-2
MDL number: MFCD00078131
PubChem Substance ID: 329823242
NACRES: NA.24 |
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PROPERTIES
grade certified reference material, pharmaceutical secondary standard
Quality Level 300
Agency traceable to BP 787, traceable to Ph. Eur. C2100000, traceable to USP 1131009
API family cholecalciferol
form solid
CofA current certificate can be downloaded
technique(s) HPLC: suitable gas chromatography (GC): suitable
mp 83-86 °C (lit.)
application(s) food and beverages
format neat
storage temp. -10 to -25°C
SMILES string CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key QYSXJUFSXHHAJI-YRZJJWOYSA-N
Gene Information human... VDR(7421)
DESCRIPTION
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.[1]
Application
Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds,[2] serum samples[3] and pharmaceutical formulations[4][2][3] by various chromatography techniques. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. Other Notes This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive. |
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